Mechanisms of D1/D2-like dopaminergic agonist, rotigotine, on lower urinary tract function in rat model of Parkinson’s disease
Parkinson’s disease [PD] is a neurodegenerative condition caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. As activation of dopaminergic receptors is fundamentally involved in the micturition reflex in PD, the objective of this study was to determine the effect of a single dose of rotigotine [[−]2-[N-propyl-N-2-thienylethylamino]-5-hydroxytetralin] on intercontraction interval [ICI] and voiding pressure [VP] in a rat model of PD. We used 27 female rats, PD was induced by injecting 6-hydroxydopamine [6-OHDA; 8 μg in 2 μL of 0.9% saline containing 0.3% ascorbic acid], and rotigotine was administrated at doses of 0.125, 0.25, or 0.5 mg/kg, either intravenous or subcutaneous injection. In rats with 6-OHDA-induced PD, intravenous injection of 0.25 or 0.5 mg/kg rotigotine led to a significantly lower ICI than after vehicle injection [p